PRZEDMIOTEM OFERTY JEST KOD DOSTĘPOWY DO KSIĄŻKI ELEKTRONICZNEJ (EBOOK)
KSIĄŻKA JEST DOSTĘPNA NA ZEWNĘTRZNEJ PLATFORMIE. KSIĄŻKA NIE JEST W POSTACI PLIKU.
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-volume set on Vitamin D*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more*Further sections on emerging uses for treatments of auto-immune diseases and diabetes*Over 600 illustrations and figures available on CD
- Autorzy: Feldman, David Pike, J. Wesley Glorieux, Francis H.
- Wydawnictwo: Elsevier S & T
- Data wydania: 2005
- Wydanie: 2
- Liczba stron: 1952
- Forma publikacji: PDF (online)
- Język publikacji: angielski
- ISBN: 9780080543642
- 9780122526879v1
- Front Cover
- Vitamin D
- Copyright Page
- Contents
- List of Contributors
- Preface to the 2nd Edition
- Preface to the 1st Edition
- Abbreviations
- Introduction
- Chapter 1. Historical Perspective
- Section I: CHEMISTRY, METABOLISM, AND CIRCULATION
- Chapter 2. Vitamin D Metabolism
- Chapter 3. Photobiology of Vitamin D
- Chapter 4. The Vitamin D 25-Hydroxylase
- Chapter 5. The 25-Hydroxyvitamin D 1- -Hydroxylase
- Chapter 6. The 25-Hydroxyvitamin D 24-Hydroxylase
- Chapter 7. Mutant Mouse Models of Vitamin D Metabolic Enzymes
- Chapter 8. Vitamin D Binding Protein
- Chapter 9. New Aspects of DBP
- Chapter 10. Endocytic Pathways for 25-(OH) Vitamin D3
- Section II: MECHANISM OF ACTION
- Chapter 11. The Vitamin D Receptor
- Chapter 12. Vitamin D Receptor Promoter and Regulation of Receptor Expression
- Chapter 13. Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription,
- Chapter 14. Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity
- Chapter 15. VDR LBD Crystal Structures
- Chapter 16. Comodulators of VDR-Mediated Gene Expression
- Chapter 17. Promoter Targeting of VDR Through A Chromatin Remodeling Complex
- Chapter 18. Molecular Basis of the Diversity of Vitamin D Target Genes
- Chapter 19. Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of
- Chapter 20. Mouse Models of Vitamin D Receptor Ablation
- Chapter 21. Intranuclear Vitamin D Response Element Binding Proteins
- Chapter 22. VDR and RXR Subcellular Trafficking
- Chapter 23. 1 ,25(OH)2–Vitamin D3 Mediated Rapid and Genomic Responses are Dependent upon Critical
- Section III: MINERAL HOMEOSTASIS
- Chapter 24. Vitamin D and the Intestinal Absorption of Calcium: A View and Overview
- Chapter 25. Intestinal Calcium Absorption: Lessons from Knockout Mice and Men
- Chapter 26. Phosphate Homeostasis
- Chapter 27. Mineralization
- Chapter 28. Modeling and Remodeling: How Bone Cells Work Together
- Chapter 29. Vitamin D and the Kidney
- Chapter 30. Vitamin D and the Parathyroids
- Chapter 31. Calcium-Sensing Receptor
- Section IV: TARGET ORGANS AND TISSUES
- Chapter 32. Bone
- Chapter 33. Cartilage and Vitamin D: Genomic and Nongenomic Regulation by 1,25(OH)2D3 and 24,25(OH)2
- Chapter 34. Dento-alveolar Bone Complex and Vitamin D
- Chapter 35. Vitamin D: Role in Skin and Hair
- Chapter 36. Regulation of Immune Responses by Vitamin D Receptor Ligands
- Chapter 37. Vitamin D and Osteoblasts
- Chapter 38. Vitamin D and Osteoclastogenesis
- Chapter 39. Vitamin D Control of the Calcitonin Gene in Thyroid C Cells
- Chapter 40. Vitamin D Regulation of Type I Collagen Expression in Bone
- Chapter 41. Target Genes: Bone Proteins
- Chapter 42. The Calbindins: Calbindin-D9K and Calbindin-D28K
- Chapter 43. Target Genes: PTHrP
- Chapter 44. Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in the Vitamin
- Chapter 45. Vitamin D and the Cellular Response to Oxidative Stress
- Section V: HUMAN PHYSIOLOGY
- Chapter 46. Vitamin D: Role in the Calcium Economy
- Chapter 47. Effects of Race, Geography, Body Habitus, Diet, and Exercise on Vitamin D Metabolism
- Chapter 48. Perinatal Vitamin D Actions
- Chapter 49. Vitamin D Deficiency and Calcium Absorption During Infancy and Childhood
- Chapter 50. Vitamin D Metabolism and Aging
- Chapter 51. Vitamin D Metabolism in Pregnancy and Lactation
- Chapter 52. Vitamin D and Reproductive Organs
- Chapter 53. Vitamin D Receptor as a Sensor for Toxic Bile Acids
- Chapter 54. Vitamin D and the Renin-Angiotensin System
- Chapter 55. Vitamin D and Muscle
- Chapter 56. Vitamin D and Cardiovascular Medicine
- 9780122526879v2
- Front Cover
- Vitamin D
- Copyright Page
- Contents
- List of Contributors
- Preface to the 2nd Edition
- Preface to the 1st Edition
- Abbreviations
- Section VI: DIAGNOSIS AND MANAGEMENT
- Chapter 57. Approach to the Patient with Metabolic Bone Disease
- Chapter 58. Detection of Vitamin D and Its Major Metabolites
- Chapter 59. Bone Histomorphometry
- Chapter 60. Radiology of Rickets and Osteomalacia
- Chapter 61. The Pharmacology of Vitamin D, Including Fortification Strategies
- Section VII: DISORDERS OF THE VITAMIN D ENDOCRINE SYSTEM
- Chapter 62. How to Define Normal Values for Serum Concentrations of 25-Hydroxyvitamin D? An Overview
- Chapter 63. Vitamin D and the Pathogenesis of Rickets and Osteomalacia
- Chapter 64. The Hypocalcemic Disorders: Differential Diagnosis and Therapeutic Use of Vitamin D
- Chapter 65. Vitamin D Deficiency and Nutritional Rickets in Children
- Chapter 66. Vitamin D Insufficiency in Adults and the Elderly
- Chapter 67. Vitamin D and Osteoporosis
- Chapter 68. Genetic Vitamin D Receptor Polymorphisms and Risk of Disease
- Chapter 69. Clinical Disorders of Phosphate Homeostasis
- Chapter 70. Disorders of Phosphate Metabolism: Autosomal Dominant Hypophosphatemic Rickets, Tumor In
- Chapter 71. Vitamin D Pseudodeficiency
- Chapter 72. Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets
- Chapter 73. Glucocorticoids and Vitamin D
- Chapter 74. Drug and Hormone Effects on Vitamin D Metabolism
- Chapter 75. Bone Disorders Associated with Gastrointestinal & Hepatobiliary Disease
- Chapter 76. Vitamin D and Renal Failure
- Chapter 77. Idiopathic Hypercalciuria and Nephrolithiasis
- Chapter 78. Hypercalcemia Due to Vitamin D Toxicity
- Chapter 79. Extra-renal 1 -hydroxylase Activity and Human Disease
- Section VIII: NEW VITAMIN D ANALOGS
- Overview
- Chapter 80. Overview: Rational Design of 1 ,25-Dihydroxyvitamin D3 Analogs (Deltanoids)
- Chapter 81. Analog Metabolism
- Chapter 82. Mechanisms for the Selective Actions of Vitamin D Analogs
- Chapter 83. Molecular Basis for Differential Action of Vitamin D Analogs
- Chapter 84. Development of New Vitamin D Analogs
- Chapter 85. Gemini: The 1,25-dihydroxy Vitamin D Analogs with Two Side-Chains
- Chapter 86. Development of OCT and ED-71
- Chapter 87. 2-Carbon-Modified Analogs of 19-Nor-1 , 25-Dihydroxyvitamin D3
- Chapter 88. Non-steroidal Analogs
- Section IX: VITAMIN D AND CANCER
- Chapter 89. Vitamin D: Cancer and Differentiation
- Chapter 90. Vitamin D, Sunlight, and the Natural History of Prostate Cancer
- Chapter 91. Epidemiology of Cancer Risk: Vitamin D and Calcium
- Chapter 92. Differentiation and the Cell Cycle
- Chapter 93. Vitamin D and Breast Cancer
- Chapter 94. Vitamin D and Prostate Cancer
- Chapter 95. Vitamin D and Colon Cancer
- Chapter 96. Vitamin D and Hematological Malignancy
- Chapter 97. Clinical Development of Calcitriol and Calcitriol Analogs in Oncology: Progress and Cons
- Section X: EMERGING USES
- Chapter 98. Vitamin D3: Autoimmunity and Immunosuppression
- Chapter 99. Vitamin D and Diabetes
- Chapter 100. Vitamin D, A Neuroactive Hormone: From Brain Development to Neurodegenerative Disorders
- Chapter 101. Psoriasis and Other Skin Diseases
- Chapter 102. Muscles and Falls
- Chapter 103. Renal Failure and Secondary Hyperparathyroidism
- Chapter 104. Inhibition of Benign Prostatic Hyperplasia by Vitamin D Receptor Ligands
- Index
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